B-cell receptor

The B-cell receptor (BCR) is an immunoglobulin molecule forming a type I transmembrane protein on the surface of B cells. The BCR transmits activatory signals into the B cell following its recognition of a specific antigen.

Latest Research and Reviews

  • Research
    | Open Access

    Leonard Goldstein et al. use high-throughput single-cell B-cell receptor sequencing on thousands of individual B cells from rat, mouse, and human repertoires. They obtained paired full-length heavy- and light-chain variable regions, and show that this approach is a powerful tool for antibody discovery.

    • Leonard D. Goldstein
    • , Ying-Jiun J. Chen
    • , Jia Wu
    • , Subhra Chaudhuri
    • , Yi-Chun Hsiao
    • , Kellen Schneider
    • , Kam Hon Hoi
    • , Zhonghua Lin
    • , Steve Guerrero
    • , Bijay S. Jaiswal
    • , Jeremy Stinson
    • , Aju Antony
    • , Kanika Bajaj Pahuja
    • , Dhaya Seshasayee
    • , Zora Modrusan
    • , Isidro Hötzel
    •  & Somasekar Seshagiri
  • Research
    | Open Access

    The immune synapse promotes cellular information exchange but the role of biophysical forces in synapse function is unclear. Here, the authors show that B cells exert two types of forces, a centripetal myosin II-driven force and a central actin protrusive force at the site of antigen extraction.

    • Anita Kumari
    • , Judith Pineau
    • , Pablo J. Sáez
    • , Mathieu Maurin
    • , Danielle Lankar
    • , Mabel San Roman
    • , Katharina Hennig
    • , Vanessa F. Boura
    • , Raphael Voituriez
    • , Mikael C. I. Karlsson
    • , Martial Balland
    • , Ana-Maria Lennon Dumenil
    •  & Paolo Pierobon
  • Reviews |

    Some immune cells undergo processes that pose unique challenges to the 3D organization of their genomes. These include antigen receptor rearrangement, clonal expansion and the contortion of their nuclei. Here, Allan and colleagues discuss the latest insights into these processes from a structural genomics perspective.

    • Timothy M. Johanson
    • , Wing Fuk Chan
    • , Christine R. Keenan
    •  & Rhys S. Allan
  • Research
    | Open Access

    Leukocytes are coated with glycans that modulate immune function through interactions with lectins. Here, the authors characterize the N-glycan repertoire of human tonsillar B cells. They report that Gal-9 is an intrinsic regulator of B cell activation that may differentially modulate BCR signaling at steady state and within germinal centers due to expression of I-branched glycans.

    • N. Giovannone
    • , J. Liang
    • , A. Antonopoulos
    • , J. Geddes Sweeney
    • , S. L. King
    • , S. M. Pochebit
    • , N. Bhattacharyya
    • , G. S. Lee
    • , A. Dell
    • , H. R. Widlund
    • , S. M. Haslam
    •  & C. J. Dimitroff
  • Research
    | Open Access

    The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9. In resting naive cells, they show that galectin-9 mediates a close association between IgM and CD22.

    • Anh Cao
    • , Nouf Alluqmani
    • , Fatima Hifza Mohammed Buhari
    • , Laabiah Wasim
    • , Logan K. Smith
    • , Andrew T. Quaile
    • , Michael Shannon
    • , Zaki Hakim
    • , Hossai Furmli
    • , Dylan M. Owen
    • , Alexei Savchenko
    •  & Bebhinn Treanor

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