Apicobasal polarity

Apicobasal polarity is a type of cell polarity specific to epithelial cells, referring to a specialised apical membrane facing the outside of the body or lumen of internal cavities, and a specialised basolateral membrane localised at the opposite side, away from the lumen. The two domains are often physically separated by adherens junctions complexes.

Latest Research and Reviews

News and Comment

  • News & Views |

    Functional single-cell liver hemi-canaliculi have been generated in a synthetic microenvironment using a reductionist approach. It is shown that the interaction between the extracellular matrix and static cadherin is sufficient to develop an apicobasal polarity independently of the contact with neighbouring cells.

    • Covadonga Díaz-Díaz
    •  & Fernando Martín-Belmonte
    Nature Materials 19, 935-937
  • Research Highlights |

    In this Journal Club, Audrey Williams and Sally Horne-Badovinac highlight the importance of studying the basal cell surface and its dynamics to understand epithelial cell behaviours and tissue rearrangements.

    • Audrey M. Williams
    •  & Sally Horne-Badovinac
  • News & Views |

    Tangential expansion of neural stem cells in the mammalian neocortex increases the number of cortical columns. A new study shows that neural stem cells that become detached from the apical surface during division regenerate an apical endfoot to ensure tangential expansion in the early stage but later lose this ability when radial expansion occurs.

    • Masafumi Tsuboi
    •  & Yukiko Gotoh
  • Research Highlights |

    A recent study published inNature Cell Biologyhas shown that tumour spheres that maintain an inverted epithelial architecture originate from primary colorectal cancers and can collectively invade the peritoneum, initiating metastasis.

    • Sarah Seton-Rogers