Amyotrophic lateral sclerosis articles from across Nature Portfolio

Reconstitution of TDP-43 filaments that exhibit sequence and morphological features similar to those found in the brain helps to uncover a new mechanism for the formation and propagation of pathology in amyotrophic lateral sclerosis and other neurodegenerative diseases.

The immune system plays a critical role in neurodegenerative diseases. Resident and peripheral immune cells contribute to disease progression. Here, the authors review the role of peripheral immune cells both when infiltrating the CNS or when remaining in the periphery.

In this Review, the authors discuss the ways in which single-cell and spatially resolved transcriptomics are contributing to our understanding of the pathophysiology of neurological conditions. They also discuss the limitations and possible future directions of these technologies.

The causes of ALS remain unclear with many proposed pathomechanisms. Here, the authors integrate iPSC-derived motor neuron and post-mortem datasets and identify a heightened DNA damage response accompanied by accumulation of somatic mutations in ALS.