Adaptive immunity

Adaptive immunity is the protection of a host organism from a pathogen or toxin. It is mediated by B cells and T cells, and is characterized by immunological memory. Adaptive immunity is highly specific to a given antigen and is highly adaptable.

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Latest Research and Reviews

  • Research | | open

    Despite the current human CD4 memory T cell stratification by CD45RA/CCR7, functional heterogeneities still exist within the respective subsets. Here the authors show that several surface markers, including KLRB1, KLRG1, GPR56 and KLRF1, help to further refine the subsetting of human CD4 memory T cells and provide insights for their differentiation.

    • Kim-Long Truong
    • , Stephan Schlickeiser
    • , Katrin Vogt
    • , David Boës
    • , Katarina Stanko
    • , Christine Appelt
    • , Mathias Streitz
    • , Gerald Grütz
    • , Nadja Stobutzki
    • , Christian Meisel
    • , Christina Iwert
    • , Stefan Tomiuk
    • , Julia K. Polansky
    • , Andreas Pascher
    • , Nina Babel
    • , Ulrik Stervbo
    • , Igor Sauer
    • , Undine Gerlach
    •  & Birgit Sawitzki
  • Research | | open

    Mucosal-associated invariant T (MAIT) cells express invariant TRAV1/TRAJ33 TCR-α gene segments and detect antigens presented by MR1. Here the authors show that atypical, MR1-restricted MAIT populations that include both Trav1+ and Trav1- cells are found in both Traj33-deficient mice and human peripheral blood.

    • Hui-Fern Koay
    • , Nicholas A. Gherardin
    • , Calvin Xu
    • , Rebecca Seneviratna
    • , Zhe Zhao
    • , Zhenjun Chen
    • , David P. Fairlie
    • , James McCluskey
    • , Daniel G. Pellicci
    • , Adam P. Uldrich
    •  & Dale I. Godfrey
  • Research |

    Tissue-resident memory T (TRM) cells have been studied mainly in mouse models. Schumacher and colleagues have developed an imaging technology to track in real time skin-resident human CD8+ TRM cells in situ.

    • Feline E. Dijkgraaf
    • , Tiago R. Matos
    • , Mark Hoogenboezem
    • , Mireille Toebes
    • , David W. Vredevoogd
    • , Marjolijn Mertz
    • , Bram van den Broek
    • , Ji-Ying Song
    • , Marcel B. M. Teunissen
    • , Rosalie M. Luiten
    • , Joost B. Beltman
    •  & Ton N. Schumacher
    Nature Immunology 20, 756-764
  • Research | | open

    New immune biomarkers of exposure to tuberculosis may require a rethink of evidence of Mycobacterium tuberculosis infection and control.

    • Lenette L. Lu
    • , Malisa T. Smith
    • , Krystle K. Q. Yu
    • , Corinne Luedemann
    • , Todd J. Suscovich
    • , Patricia S. Grace
    • , Adam Cain
    • , Wen Han Yu
    • , Tanya R. McKitrick
    • , Douglas Lauffenburger
    • , Richard D. Cummings
    • , Harriet Mayanja-Kizza
    • , Thomas R. Hawn
    • , W. Henry Boom
    • , Catherine M. Stein
    • , Sarah M. Fortune
    • , Chetan Seshadri
    •  & Galit Alter
  • Research | | open

    Both thymic epithelial cells and dendritic cells present self antigens in the thymus to mediate thymic selection and T cell tolerance. Here the authors quantify, using two-photon live imaging of mouse thymic slices, the relative contribution of these two cell types, as well as the effects of antigen cross-presentation by dendritic cells, during tolerance induction.

    • J. N. Lancaster
    • , H. M. Thyagarajan
    • , J. Srinivasan
    • , Y. Li
    • , Z. Hu
    •  & L. I. R. Ehrlich

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