In a lamb model, Hütten et al. found that automated control of the fraction of inspired oxygen not only was feasible in preterm resuscitation but also significantly reduced hyperoxia compared with manual FiO2 control. See the article on page 657. Photos courtesy of Matthias C. Hütten. Cover design by Erin Dewalt.

Chest radiograph of an intubated and ventilated baby infected with respiratory syncytial virus (RSV). Typical abnormalities can be seen: bilateral patchy infiltrates, atelectasis of the right upper lobe, and hyperinflation. In this issue, Mangodt and coauthors review the roles of T helper 17 cells and regulatory T cells in the pathogenesis of RSV. See the article on p. 483. Image courtesy of Antwerp University Hospital. Cover design by Erin Dewalt.

Lam et al. studied the ontogeny of P-glycoprotein in the developing brain and its effect on newborns’ sensitivity to opioid toxicity. Photo from IPGGutenbergUKLtd/iStock/Thinkstock. See the article on p. 417.

In this issue, Patel and Denning review the protective and pathologic roles of intestinal microbiota in necrotizing enterocolitis. See the Clinical Review on p. 232. Image courtesy of Patricia Denning.

Yang and co-researchers review the safety and efficacy of acupuncture in children, and make suggestions for future studies. See p. 112

In this issue, Nasr and Davis review the effects of anesthetic exposure in the developing brain and highlight the need for more clinical trials of anesthetic agents commonly used in newborns. See the article on p. 2