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Volume 15 Issue 1, January 2008

Internal ribosomal entry sites help initiate translation of some viral transcripts. Kieft and colleagues present the structure of a Dicistroviridae IRES domain. Its structural mimicry of the host tRNA-mRNA interaction suggests how this RNA is able to kick start translation alone. This molecular mimicry is represented by organismal mimicry in the cover photograph by Ra'id Khalil, from istockphoto.com.pp 57-64

Volume 15 Issue 1

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  • Stuttering by telomerase contributes to the natural heterogeneity of fission yeast telomeric repeat sequences.

    • Manuel Ares Jr.
    • Kausik Chakrabarti
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  • DNA damage activates signaling cascades driven by the ATM–ATR protein kinases, culminating in the recruitment of repair proteins to the damage site through poorly understood mechanisms. Now a flurry of papers reveals how ATM-dependent phosphorylation of mediator and chromatin-associated proteins at sites of double-strand breaks promotes ubiquitylation of local nucleosomes, thereby eliciting a powerful signal for recruitment of repair complexes to the damage site.

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    • J Wade Harper
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