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Rhodopsin is a G protein–coupled receptor (GPCR) involved in biological signaling. How the structure of the ligand is connected with larger-scale functional protein dynamics has remained elusive. Solid-state NMR relaxation shows that localized motions of the ligand retinal lead to collective fluctuations of transmembrane helices in the activation mechanism of the photoreceptor.
XMRV is a retrovirus that has been linked to prostate cancer and chronic fatigue syndrome. The crystal structure of the XMRV protease differs from the structures of other retropepsins and instead resembles those of pepsin-like enzymes, suggesting that this protease may represent a distinct evolutionary branch of the aspartic proteases.
