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Integrative database analysis in structural genomics

Nature Structural Biology volume 7, pages 960–963 (2000)Cite this article

Abstract

An important aspect of structural genomics is connecting coordinate data with whole-genome information related to phylogenetic occurrence, protein function, gene expression, and protein–protein interactions. Integrative database analysis allows one to survey the 'finite parts list' of protein folds from many perspectives, highlighting certain folds and structural features that stand out in particular ways.

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Figure 1: An example of structural genomics data integration is shown for yeast.
Figure 2: Results of an integrated database analysis on the relationship between fold, function and interactions and its implications for structural genomics.

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Acknowledgements

Thanks are given to M. Schultz, N. Luscombe, D. Greenbaum, J. Junker, P. Bertone, W. Krebs, P. Miller, and K. Cheung for carefully reading the draft; to S. Teichmann and J. Park for helping with protein–protein interaction numbers for the figures; and to the NIH and Keck foundation for financial support.

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  1. Department of Molecular Biophysics & Biochemistry, 266 Whitney Avenue

    Mark Gerstein

  2. Yale University, PO Box 208114, New Haven, 06520 , Connecticut, USA

    Mark Gerstein

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Gerstein, M. Integrative database analysis in structural genomics. Nat Struct Mol Biol 7 (Suppl 11), 960–963 (2000). https://doi.org/10.1038/80739

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