A recent Rinshoken conference featuring adgerents of both X-ray crystallography and NMR emphasized the need for using a combination of approaches to solve the sturctures of large molecules.
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Arata, Y. Size is everything. Nat Struct Mol Biol 4, 93–94 (1997). https://doi.org/10.1038/nsb0297-93
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DOI: https://doi.org/10.1038/nsb0297-93