The identification of a second regulatory checkpoint controlling RNA polymerase II elongation near the poly(A) site of protein-coding genes reveals an additional level of complexity in the modulation of eukaryotic transcriptional elongation and termination.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Bartkowiak, B. et al. Genes Dev. 24, 2303–2316 (2010).
Heidemann, M., Hintermair, C., Voss, K. & Eick, D. Biochim. Biophys. Acta 1829, 55–62 (2013).
Muñoz, M.J. et al. Cell 137, 708–720 (2009).
Laitem, C. et al. Nat. Struct. Mol. Biol. 22, 396–403 (2015).
Proudfoot, N.J. Genes Dev. 25, 1770–1782 (2011).
West, S., Gromak, N. & Proudfoot, N.J. Nature 432, 522–525 (2004).
Merino, E. & Yanofsky, C. Trends Genet. 21, 260–264 (2005).
Tilgner, H. et al. Nat. Struct. Mol. Biol. 16, 996–1001 (2009).
Spies, N., Nielsen, C.B., Padgett, R.A. & Burge, C.B. Mol. Cell 36, 245–254 (2009).
Schwartz, S., Meshorer, E. & Ast, G. Nat. Struct. Mol. Biol. 16, 990–995 (2009).
Kwak, H., Fuda, N.J., Core, L.J. & Lis, J.T. Science 339, 950–953 (2013).
Hodges, C., Bintu, L., Lubkowska, L., Kashlev, M. & Bustamante, C. Science 325, 626–628 (2009).
Kornblihtt, A.R. et al. Nat. Rev. Mol. Cell Biol. 14, 153–165 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Giono, L., Kornblihtt, A. A bumpy road for RNA polymerase II. Nat Struct Mol Biol 22, 353–355 (2015). https://doi.org/10.1038/nsmb.3020
Published:
Issue Date:
DOI: https://doi.org/10.1038/nsmb.3020