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Designs on a curve

Nature Structural & Molecular Biology volume 22, pages 103–105 (2015)Cite this article

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The structural rules governing the curving folds of solenoid proteins, as distilled down to the level of the underlying sequence repeats, provide designers with the tools to reliably fashion new variants with tunable geometries. Bespoke leucine-rich repeat (LRR) scaffolds, as recognition proteins, can now be tailored to better fit their targets.

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Figure 1: Overview of the main steps of the design procedure applied by Baker and co-workers6.
Figure 2: Different examples of curved solenoid proteins (green ribbon) bound to globular proteins or DNA (yellow and orange surfaces).

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References

  1. Wolynes, P.G. Proc. Natl. Acad. Sci. USA 93, 14249–14255 (1996).

    Article  CAS  Google Scholar 

  2. Blaber, M., Lee, J. & Longo, L. Cell. Mol. Life Sci. 69, 3999–4006 (2012).

    Article  CAS  Google Scholar 

  3. Kajava, A.V. J. Struct. Biol. 179, 279–288 (2012).

    Article  CAS  Google Scholar 

  4. Kobe, B. & Kajava, A.V. Trends Biochem. Sci. 25, 509–515 (2000).

    Article  CAS  Google Scholar 

  5. Rämisch, S. et al. Proc. Natl. Acad. Sci. USA 111, 17875–17880 (2014).

    Article  Google Scholar 

  6. Park, K. et al. Nat. Struct. Mol. Biol. 22, 167–174 (2015).

    Article  CAS  Google Scholar 

  7. Baretic´, D. & Williams, R.L. Curr. Opin. Struct. Biol. 29, 134–142 (2014).

    Article  Google Scholar 

  8. Han, Z., Sun, Y. & Chai, J. Curr. Opin. Plant Biol. 20, 55–63 (2014).

    Article  CAS  Google Scholar 

  9. Enkhbayar, P. et al. J. Proteomics Bioinform. 7, 139–150 (2014).

    Article  Google Scholar 

  10. Miyashita, H. et al. Protein Pept. Lett. 21, 292–305 (2014).

    Article  CAS  Google Scholar 

  11. Javadi, Y. & Itzhaki, L.S. Curr. Opin. Struct. Biol. 23, 622–631 (2013).

    Article  CAS  Google Scholar 

  12. Main, E.R.G., Jackson, S.E. & Regan, L. Curr. Opin. Struct. Biol. 13, 482–489 (2003).

    Article  CAS  Google Scholar 

  13. Schilling, J., Schöppe, J. & Plückthun, A. J. Mol. Biol. 426, 691–721 (2014).

    Article  CAS  Google Scholar 

  14. Koga, N. et al. Nature 491, 222–227 (2012).

    Article  CAS  Google Scholar 

  15. Parmeggiani, F. et al. J. Mol. Biol. 427, 563–575 (2015).

    Article  CAS  Google Scholar 

  16. Voet, A.R.D. et al. Proc. Natl. Acad. Sci. USA 111, 15102–15107 (2014).

    Article  CAS  Google Scholar 

  17. Hindle, K.L., Bella, J. & Lovell, S.C. Proteins 77, 342–358 (2009).

    Article  CAS  Google Scholar 

  18. Schreiber, G. & Fleishman, S.J. Curr. Opin. Struct. Biol. 23, 903–910 (2013).

    Article  CAS  Google Scholar 

  19. Lee, S.C. et al. Proc. Natl. Acad. Sci. USA 109, 3299–3304 (2012).

    Article  CAS  Google Scholar 

  20. Ng, A.C. et al. Proc. Natl. Acad. Sci. USA 108 (suppl. 1), 4631–4638 (2011).

    Article  CAS  Google Scholar 

  21. Özkan, E. et al. Cell 154, 228–239 (2013).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. and the Department of Pharmacology, J. Fernando Bazan is at Bio-Techne Corporation, Minneapolis, Minnesota, USA, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA.,

    J Fernando Bazan

  2. Andrey V. Kajava is at the Centre de Recherche de Biochimie Macromoléculaire, CNRS, University of Montpellier, Montpellier, France.,

    Andrey V Kajava

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  1. J Fernando Bazan
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  2. Andrey V Kajava
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Correspondence to J Fernando Bazan or Andrey V Kajava.

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The authors declare no competing financial interests.

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Bazan, J., Kajava, A. Designs on a curve. Nat Struct Mol Biol 22, 103–105 (2015). https://doi.org/10.1038/nsmb.2966

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