Biochemical studies on the spliceosomal helicase Brr2 reveal that it is activated by Prp8, the master regulator of the splicing cycle. Substitutions in Prp8 that cause retinal degeneration in humans block activation of Brr2, providing insight into the molecular pathology of retinitis pigmentosa.
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Brow, D. Eye on RNA unwinding. Nat Struct Mol Biol 16, 7–8 (2009). https://doi.org/10.1038/nsmb0109-7
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DOI: https://doi.org/10.1038/nsmb0109-7
