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To support urgent research to combat the ongoing outbreak of COVID-19, caused by the novel coronavirus SARS-CoV-2, the editorial teams at Nature Research have curated a collection of relevant articles.
This special Focus on Targeting Chromatin features Reviews, Perspectives and a Comment that discuss chromatin-associated proteins that are the subject of current drug-development efforts, highlighting chromatin processes as promising targets for therapeutic intervention.
This collection includes recent articles from across the Nature group of journals and showcases both the latest advances in the methodologies used to study genome organization, and our recent understanding of how genome organization and nuclear architecture regulate gene expression, cell fate and cell function in physiology and disease.
To mark the 50th anniversary of the discovery of the three nuclear RNA polymerases, we feature a collection of Perspective and Review pieces that narrate the history of eukaryotic transcription research from a personal perspective.
Image: Art by Erin Dewalt, inspired by the concept of “ever-expanding complexity”.
Daily rhythms are an integral part of life. This special Focus on 'Cycles and Rhythms' features Reviews and a Perspective that explore the molecular mechanisms that drive oscillatory behaviour and that underlie the generation of metabolic and circadian dynamics.
Membrane proteins are central to many physiological processes and are targeted by ~50% of marketed pharmaceutical drugs. Determining the structures of membrane proteins is essential for understanding their function and for drug design. This Focus highlights the latest breakthroughs in elucidating the structure and mechanisms of ABC transporters and neurotransmitter-gated ion channels; it also explores recent technical and methodological advances in X-ray crystallography, cryo-EM, NMR and computational approaches to investigate membrane proteins.
The progressive shortening of telomeres with each cell division determines cellular replicative capacity and ultimately induces cellular senescence. This Focus brings to light the complex interactions of telomerase and shelterin components in telomere length maintenance, the role of DNA damage-response factors in telomere replication and processing, and the consequences of telomere dysfunction in human disease and cancer cell proliferation.