Our December issue includes Reviews on repurposing of existing drugs for Alzheimer disease, new insights and challenges in spinal muscular atrophy now that effective treatment is available, precision medicine strategies in epilepsy, and peripheral sodium channel blockers for the treatment of pain.

Our 15th anniversary issue includes a series of Comment articles that examine fields in which considerable progress has been made but a change of thinking might now be needed. It also includes two articles on neurological aspects of COVID-19, consensus recommendations for the diagnosis of malformations of cortical development, and a Review on the role of complement in neurological disorders.

Our October issue includes articles on therapeutic advances in Huntington disease, metagenomic next-generation sequencing for the diagnosis of neurological infections, molecular subtypes of brain metastases and their management, and the potential of artificial intelligence for image analysis to improve stroke care.

Our September issue includes articles on immunotherapy in the COVID-19 era, B cell biology in autoantibody-mediated diseases, CRISPR-based functional genomics, and microRNA targeting in epilepsy.

Our August issue includes articles on the use of virtual reality in people with Parkinson disease, nodes of Ranvier during CNS development and repair, and applications of machine learning to neurodegenerative disease.

Our July issue includes articles on GAD antibodies in neurological disorders, the polygenic architecture of schizophrenia, and the development of biomarkers for pain.

Our June issue includes articles on Parkinson disease and the immune system, cognitive dysfunction in patients with multiple sclerosis, and the relationship between zoonotic and vector-borne parasites and epilepsy.

Our May issue includes articles on multilevel omics in stroke, inflammation in acquired hydrocephalus and blood-based biomarkers for non-Alzheimer neurodegenerative disorders.

Our April issue includes articles on protein transmission in neurodegenerative disease, multi-target approaches to CNS repair, and disease-modifying drugs for frontotemporal dementia spectrum disorders.

Our March issue includes articles on perivascular spaces in the brain, neuromyelitis optica spectrum disorders and pregnancy, and brain and spinal cord atrophy measures in multiple sclerosis.

Our February issue includes articles on essential tremor, degenerative cervical myelopathy, sex differences in movement disorders and LRRK2 in Parkinson disease.

Our January issue includes articles on cerebral amyloid angiopathy, cannabinoids in neurological disorders, post-stroke aphasia and immune reconstitution therapies for multiple sclerosis.