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Wilson's disease is an inherited disorder of copper metabolism caused by a mutation in the copper-transporting gene ATP7B, and it results in excessive copper accumulation in the liver and brain. In this Review, the authors provide a comprehensive description of the disease's pathogenesis and neurological clinical presentation, and discuss the diagnosis and treatment options currently available.
Gliomas—tumors of glial cell origin—account for the majority of primary malignant brain tumors, and they are often associated with a very poor prognosis. It is hoped that by identifying genetic, behavioral, environmental and developmental contributors to glioma risk, and understanding how these various factors interact, the disease burden can ultimately be reduced.
Bacterial meningitis is associated with numerous complications, including meningoencephalitis, stroke and raised intracranial pressure. In this Review, van de Beek et al. discuss potential adjunctive therapies for managing these types of complications, citing data from both experimental and clinical studies. They also consider future adjunctive strategies that are currently being investigated in animal models.