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Even advanced sclerotic glomeruli show ongoing cell turnover, indicating that there is potential for modulation of the progressive renal scarring seen in chronic kidney disease. Agnes Fogo examines the mechanisms of glomerulosclerosis, with a particular focus on the pivotal role of angiotensin, and considers the potential reversibility of the processes involved.
In the third article of our series on secondary hyperparathyroidism in renal disease, Joachim Ix and colleagues comment on the recommendations put forth by Matthieu Monge et al. on page 326. Ix et al. contend that the changes to current practice proposed by Monge and colleagues are supported by insufficient evidence and should be revisited only when more data from high-quality trials become available.