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Collaboration is key when it comes to mounting an effective T cell response against cancer. A new study shows that CD4+ T cell activation in a tumour is required to support effective priming and cytotoxic activity of tumour-infiltrating CD8+ T cells.
A new study has identified genetic variants of the anti-inflammatory signalling molecule A20 that can be traced back to archaic humans and affect microbial resistance versus tolerance.
Connie Wong describes a 2003 paper by Andreas Meisel and colleagues linking post-stroke systemic immunosuppression to effects of the sympathetic nervous system on immune cells.
Commensal viruses in the intestine support the proliferation and survival of intraepithelial lymphocytes through RIG-I-dependent IL-15 production and therefore contribute to healthy gut homeostasis.
Universal cells — here defined as cells that are invisible to the immune system — could potentially have many uses in transplantation medicine. This Review discusses how far we have come in creating such cells and the lessons that nature can teach us about immune evasion.
The authors consider the inflammatory basis of type 1 and type 2 diabetes. In particular, they focus on the role of IL-1β in both diseases and discuss the feasibility of targeting innate immune mechanisms in the clinic.
Platelets are best known for their roles in haemostasis, but they also contribute to host immunity. In this Review, Gaertner and Massberg consider how platelets ‘patrol the vascular highway’ to shape immune responses during infection and cancer.
Recent advances in single-cell antibody cloning technologies have enabled the molecular characterization of monoclonal antibodies against Plasmodium falciparum parasites, which has significantly enhanced our understanding of how these antibodies are generated, as well as their epitope specificity and binding modes.
