Volume 18 Issue 12, December 2018

Volume 18 Issue 12

‘Heart of a snowman’, inspired by the Review on p733

Cover design: Simon Bradbrook

Research Highlights

  • Research Highlight |

    Transcriptomics used to map variation in innate immune responses across species.

    • Yvonne Bordon
  • Research Highlight |

    Eukaryotic translation initiation complex eIF4F is identified as an upstream regulator of PD-L1 expression and is therefore a promising target for immunotherapy.

    • Katie Kingwell
  • Research Highlight |

    A new guide to immunopharmacology seeks to bring the most valuable pharmacological data into the hands of immunology researchers.

    • Simon D. Harding
    • , Elena Faccenda
    • , Chris Southan
    • , Pasquale Maffia
    •  & Jamie A. Davies
  • Research Highlight |

    CD4+ T cell cytokines in the intestinal crypts balance intestinal stem cell renewal and differentiation.

    • Lucy Bird
  • Research Highlight |

    Using spiky microparticles, the authors show that physical cues, such as topological features on the surface of a pathogen, can trigger an immune response by exerting mechanical stress on immune cells.

    • Kirsty Minton
  • Research Highlight |

    Two studies describe distinct mechanisms of resistance to anti-CD19 chimeric antigen receptor (CAR) T cell therapy in relapsed leukaemia patients

    • Ulrike Harjes


  • Review Article |

    Recent studies have characterized complex interactions between resident and infiltrating immune cells in the heart and cardiac cells, including cardiomyocytes, fibroblasts and endothelial cells. This Review explores the role of immune cells in cardiac development and physiological function, as well as heart disease.

    • Filip K. Swirski
    •  & Matthias Nahrendorf
  • Review Article |

    A-DAM good Review discussing the role of ADAM protein-mediated cleavage of a wide range of substrates in the development and regulation of the immune system, with a focus on ADAM10 and ADAM17.

    • Bart N. Lambrecht
    • , Matthias Vanderkerken
    •  & Hamida Hammad