Volume 12 Issue 10, October 2012

BCR signals during B cell development determine the level of B cell anergy.

MYD88 signalling can have pro- or anti-tumorigenic effects in distinct cancer models.

A highIL2/IFNGmRNA ratio identifies rare tumour-specific T cells that can persist in humans following adoptive transfer.

Researchers identify a new AIDS-like disease caused by IFNγ-specific autoantibodies.

Unlicensed natural killer cells are important in the response of patients with high-risk neuroblastoma to treatment with GD2-specific monoclonal antibodies.

Activated autoimmune T cells acquire a migratory phenotype in the lungs prior to CNS invasion.

Inflammatory monocytes activate memory CD8⁺T cells in an antigen-independent manner.

Neutrophils releasing NETs remain functional in response to infection.

The evolutionary 'arms race' between host restriction factors and viral antagonists has left a genetic 'signature' that can tell us much about the innate immune response to past and present viral infections.

Dietary habits have always been associated with the robustness of the immune system. Here, the molecular links between dietary compounds and immune regulation in the intestine are discussed, with a focus on the central role of nuclear receptors.

Here, Patrick Wilson and Sarah Andrews discuss the strategies that have been used to identify rare broadly neutralizing antibodies, focusing on the recent advances in isolating such antibodies naturally generated in response to HIV and influenza virus infection or vaccination.

In this Opinion, the authors describe an unconventional form of peptide recognition that can allow potentially autoreactive CD4⁺T cells to escape thymic regulation. They explain how these T cells respond to unstable peptide—MHC complexes that evade H2-DM-mediated editing, and they discuss the implications for autoimmunity.

Here,Nature Reviews Immunologyasks four experts to share their thoughts on the ability of probiotics and prebiotics to modulate the immune system and influence disease. Can these products have a therapeutic application for inflammatory diseases?

What is the role and value of consortium biology in immunology? Here, the participants of the Immunological Genome Project share their thoughts on the benefits and shortcomings of 'big science' and discuss how the immunology community can profit from engaging in this type of discovery-led research.