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Bali Pulendran provides a historical overview of the development of the successful yellow fever vaccine. He describes recent advancements in our understanding of its mechanisms of action resulting from the use of systems biological approaches and how this knowledge might be applicable to vaccine development in general.
This Timeline article provides an overview of the discovery and proposed mechanisms of action of aluminium salts, the most widely used vaccine adjuvants. The recent progresses and outstanding controversies on how aluminium salts function as adjuvants are also discussed.
