News & Comment

Group 2 innate lymphoid cells promote beiging of adipose tissue and protect against obesity.

Bacteria in the gut that cross-react with malarial parasites can induce the production of protective natural antibodies.

NLRC4 activation bySalmonellaalters cytoskeletal dynamics to reduce intracellular bacterial burden.

Human memory CD4⁺ T cells primed in vivoby pathogens or vaccines are highly heterogeneous.

Macrophages capture HIV-1-infected CD4⁺T cells, which results in robust macrophage infection.

Nucleoside reverse transcriptase inhibitors target P2X7-dependent inflammasome activation to mediate anti-inflammatory effects.

Seven new studies advance our understanding of immune checkpoint blockade and highlight an approach for developing personalized cancer vaccines.

An enteric RNA virus can substitute for commensal bacteria and support immune maturation and intestinal homeostasis.

Brozet al. identify a rare intratumoral CD103⁺dendritic cell population that stimulates cytotoxic T cells.

Respiratory infection with influenza virus causes intestinal symptoms through the specific recruitment of lung-induced CD4⁺T cells to the intestinal mucosa.

The induction of a type I interferon response in cancer cells is linked to the efficacy of certain chemotherapies.

A new study identifies a ubiquitously expressed ribosomal protein that is recognized by arthritogenic T cells.

Autophagy is important for the transition of effector CD8⁺T cells into memory T cells.

Superspreaders ofSalmonellainfection are uniquely able to tolerate antibiotic treatment.

A new study of individuals deficient for the ubiquitin-like protein ISG15 demonstrates a role for this molecule in regulating the type I IFN response.

Chitinase-like proteins promote innate interleukin-17 production and neutrophilia.

Clostridium difficileinfection induces the expression of interleukin-22, which regulates the complement system to eliminate systemically translocated pathobionts.

Fucosylation of intestinal epithelial cells in response to commensal or systemic bacterial stimulation promotes disease resistance and tolerance through the metabolic support of the gut microbiota.

Distinct subsets of thymic antigen-presenting cells contribute to the generation of a diverse and self-tolerant T cell repertoire.

LOX1 activates dendritic cells and B cells to boost humoral immune responses.