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  • A unique population of TRegcells accumulates in injured muscles and promotes muscle repair.

    • Olive Leavy
    Research Highlight

  • Pathogenic mycobacteria use membrane lipids to evade detection by TLRs and killing by microbicidal macrophages.

    • Elisabeth Kugelberg
    Research Highlight

  • Intracellular production of C3a in human CD4+T cells mediated by cathepsin L is required for T cell survival and effector function.

    • Kirsty Minton
    Research Highlight

  • Interleukin-10-producing B cells in adipose tissues limit obesity-associated inflammation.

    • Lucy Bird
    Research Highlight

  • The generation of TLR8 transgenic mice reveals a role for this receptor in autoimmune disease.

    • Elisabeth Kugelberg
    Research Highlight

  • Antibiotics disrupt the microflora and impair the efficacy of cancer therapies.

    • Yvonne Bordon
    Research Highlight

  • Neonatal erythroid cells actively suppress immune responses against microbes.

    • Yvonne Bordon
    Research Highlight

  • Bona fide TRegcells can become unstable during an autoimmune response.

    • Olive Leavy
    Research Highlight

  • Two newStaphylococcus aureusvirulence factors convert neutrophil extracellular traps (NETs) to deoxyadenosine, which triggers macrophage apoptosis.

    • Andrea Du Toit
    Research Highlight

  • The bacterial by-product butyrate affects histone acetylation ofFoxp3 and thereby promotes peripheral TRegcell differentiation.

    • Elisabeth Kugelberg
    Research Highlight

  • Antibodies come to the fore in therapeutic and prophylactic approaches to suppress SHIV in macaques.

    • Lucy Bird
    Research Highlight

  • The histone deacetylase HDAC3 in IECs regulates host–commensal bacteria interactions and maintains intestinal homeostasis.

    • Elisabeth Kugelberg
    Research Highlight

  • Adenosine regulates thymocyte development and maintains peripheral naive T cells through the regulation of IL-7Rα expression.

    • Olive Leavy
    Research Highlight

  • CCR4-specific antibodies deplete regulatory T cells and boost antitumour responses in humans.

    • Yvonne Bordon
    Research Highlight

  • IgE responses to venom protect animals against potentially lethal subsequent exposures to the venom.

    • Yvonne Bordon
    Research Highlight

  • Genes and environment contribute to a vast diversity of human NK cell phenotypes.

    • Olive Leavy
    Research Highlight

  • Phosphorylation of Mef2 controls immune versus metabolic gene expression in infectedDrosophila melanogaster.

    • Lucy Bird
    Research Highlight