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  • Activation of TGFβ signalling in invasive margins of metastatic tumours can contribute to T cell exclusion and reduced immune checkpoint therapy response.

    • Ulrike Harjes
    Research Highlight

  • Gut commensals induce systemic IgA responses that protect mice against lethal sepsis.

    • Yvonne Bordon
    Research Highlight

  • Quiescent adult stem cells escape immune surveillance by downregulating the antigen presentation machinery.

    • Grant Otto
    Research Highlight

  • Pathobiont-specific peripherally derived regulatory T cells have an important role in maintaining gut homeostasis.

    • Kirsty Minton
    Research Highlight

  • NK cells recruit cDC1s to the tumour microenviroment by producing the chemokines CCL5 and XCL1.

    • Yvonne Bordon
    Research Highlight

  • Intratumoural vaccination with immune-enhancing agents eradicates tumour metastases.

    • Lucy Bird
    Research Highlight

  • Chimeric antigen receptors that provide an antigen-dependent signal 3 to T cells have improved antitumour efficacy.

    • Kirsty Minton
    Research Highlight

  • ER adaptor protein identified as key sensor of the bacterial cyclic dinucleotide c-di-AMP.

    • Lucy Bird
    Research Highlight

  • Group 2 innate lymphoid cells present endogenous lipids via CD1a to skin-resident T cells

    • Shimona Starling
    Research Highlight