News & Comment

Pallaschet al. report an important mechanism through which therapeutic antibodies can induce tumour cell death, and they give an insight into how resistance can develop and be overcome.

Intestinal CX₃CR1⁺ macrophages can transfer processed antigen to CD103⁺DCs through gap junctions for the induction of oral tolerance.

Antibiotics can promote allergy by leading to the outgrowth of commensal fungi.

A unique population of memory T_Regcells resides in healthy human skin.

Programmed cell death 1 has a regulatory role in the antigen response by CD4⁺effector T cells.

Components of the unfolded protein response regulate CD8α⁺dendritic cell function and plasma cell survival.

A committed precursor for innate lymphoid cells is identified in mice.

T helper cells producing IL-9 have been identified in healthy and psoriatic human skin.

Vitamin A deficiency shifts the balance of innate lymphoid cell subsets in the gut.

MDR1 expression distinguishes pathogenic from non-pathogenic T_H17 cells in humans.

The prevalence of MHC class I molecules that present conserved immunogenic influenza A virus peptides varies among ethnicities.

Natural skin oils activate CD1a-restricted T cells for barrier immunity.

Soluble lymphotoxin and membrane-bound lymphotoxin produced by innate lymphoid cells control the generation of IgA in the gut.

A high-fat diet promotes airway inflammation through IL-17A⁺innate lymphoid cells, whereas a high-fibre diet reduces airway inflammation through effects on dendritic cells.

The identification of CD4⁺T cells that are specific for the wake-promoting hormone orexin confirms narcolepsy as an autoimmune disease.