News & Comment

Interleukin-1 confers resistance to tuberculosis through the induction of eicosanoids that antagonize type I interferons.

Memory T cells synthesize the substrates for metabolic reprogramming to fatty acid oxidation in a cell-intrinsic manner.

Porphyromonas gingivalisevades immune-mediated killing and promotes inflammation to ensure its survival and drive dysbiosis.

Intracellular infection induces type III interferon production from peroxisomes.

NLRP3 inflammasomes can act extracellularly and thereby amplify the inflammatory response.

Interferon-γ production by memory T cells drives faster and more effective innate immune cell responses.

Combining CXCR2 blockade with PD1 blockade overcomes multiple mechanisms of tumour immune evasion.

Activation of the pyrin inflammasome is induced by bacterial modification of RHO GTPases.

TFEB is an evolutionarily ancient transcription factor that regulates the host response to bacterial infections.

Interleukin-9 secreted by T helper 9 cells impairs intestinal barrier function and exacerbates ulcerative colitis.

The type 2 cytokines IL-4 and IL-13 induce beige fat thermogenesis through catecholamine secretion by alternatively activated macrophages.

Bacteria-induced recruitment of neutrophils could have a role in the pathogenesis of graft-versus-host disease.

The liver clears commensal bacteria that have breached intestinal defences.

Increased expression of S1PR2 in the female central nervous system may contribute to the development of multiple sclerosis.

IL-10 induced by malaria infection renders the host susceptible to concurrent bacterial infection.

Tissue-specific factors control the phenotype, localization, proliferative renewal and function of peritoneal macrophages.

The nuclear envelope protein lamin A modulates T cell activation by linking processes at the plasma membrane, cytoplasm and nucleus.

A subset of sensory neurons in the skin is essential for IL-23 production in a model of psoriasis.

The soluble pattern-recognition molecule pentraxin-related protein 3 is important for protection against urinary tract infections.

T cell receptor signalling downregulates p53 expression to enable antigen-stimulated T cells to enter the cell cycle.