News & Comment

Epigenetic remodelling and changes in cellular metabolism are required for memory-like responses in innate immune cells.

Recombination-activating gene (RAG) proteins determine functional specialization and cellular fitness in natural killer cells.

CD4⁺T cells in newborn babies show increased production of CXCL8, which could be important for defence against infections.

Whether neutrophils kill a pathogen by phagocytosis or NETosis is determined by pathogen size.

Activation of tissue-resident memory CD8⁺T cells leads to a state of pathogen alert that induces both innate and adaptive immune responses.

Intestinal bacteria stimulate TLR5 on B cells and macrophages to promote antibody responses to subunit vaccination.

New vaccine protects monkeys from Ebola virus.

The transcription factor BCL-6 suppresses the expression of a subset of important genes in the glycolytic pathway in transitional effector T cells.

The TAM receptors MER and AXL regulate apoptotic cell uptake in diverse immune settings.

Invariant natural killer T cells can directly limit bacterial dissemination into the joints.

Dectin 2 specifically binds the mycobacterial cell wall component mannose-capped lipoarabinomannan.

FLT3L-activated classical dendritic cells (DCs) drive immune responses following subcutaneous immunization, whereas migratory skin DCs dampen them.

A new study identifies inflammatory caspases as the cytoplasmic LPS receptors that trigger non-canonical inflammasome activation.

In response to intestinal tissue damage, the alarmin interleukin-33 enhances local regulatory T cell responses.

Pulmonary epithelial cells drive rhythmic neutrophil recruitment by secreting chemokines in a clock-dependent manner.

NOD2 restricts small intestinal inflammation by controlling the overgrowth of commensal bacteria.

Eosinophils initiate T helper 2 cell responses in the small intestine by promoting dendritic cell activation.

Linear ubiquitylation of the adaptor protein ASC regulates interleukin-1β production by the NLRP3 inflammasome.

Regulatory T cells suppress effector T cells by releasing exosomes that contain microRNAs.

CD4⁺T cells detect beryllium hidden within peptide–MHC class II complexes.