News & Comment

Braumüller, Wieder and colleagues show that T helper 1 cells induce the senescence of tumour cells.

Virus-specific memory-like CD4⁺T cells can be abundant in humans who have not been infected with the virus.

MCL1 and autophagy promote plasma cell survival.

Caspase 11 promotes host protection during infection with cytosolic bacteria.

Sex differences in the gut microbiota promote testosterone-mediated protection from type 1 diabetes.

LL-37 produced by HSV-2-infected keratinocytes increases the susceptibility of neighbouring Langerhans cells to HIV infection.

Defects in the engulfment of dead cells by airway epithelial cells can contribute to allergic inflammation.

Intestinal effector CD4⁺ T cells downregulate THPOK to differentiate into CD4⁺CD8α⁺CTLs.

B cells secrete the neurotransmitter acetylcholine to control neutrophil recruitment.

T-bet instructs the development of IFNγ-producing innate lymphoid cells in mice and humans.

Caspase 8 inhibits ripoptosome-mediated activation of the NLRP3 inflammasome.

Perivascular mast cells in the skin extend projections into the blood vessel lumen to acquire circulating IgE.

Prolonged IL-7-mediated signalling in CD8⁺T cells induces apoptosis.

Loss of the dopamine D2 receptor or activation of the NLRP3 inflammasome can enhance CNS inflammation and contribute to neurodegenerative disease.