Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A study in Immunity reports that a high-fat diet in mice leads to the loss of PPARγ+ Treg cells in the skin, which exacerbates psoriasis mediated by IL-17-producing γδ T cells.
A preprint by Ramanan et al. examines the roles of accessory transcription factors in regulating subsets of colonic regulatory T cells, independently of the microbiota and T cell specificity.
Individuals with the HLA-B*15:01 allele may have pre-existing T cells derived from seasonal coronavirus infections that cross-protect against SARS-CoV-2.
This Comment article proposes that the transfer of surface molecules between interacting cells by trogocytosis might affect the cellular specificity of monoclonal antibodies, as well as the functionality of receiving cells.
In contrast to its role in promoting immune responses to viral and bacterial infections, STING inhibits SYK-dependent cytokine production in response to fungal infection.
A preprint by Nakandakari-Higa et al. introduces universal LIPSTIC (uLIPSTIC), a labelling technique for the detection of physical interactions between any cell types without the requirement for specific receptor–ligand interaction.
In this Tools of the Trade article, Christa Haase (at the Charles Lin lab) describes a technique called Image-seq that enables image-guided cell isolation from a specific, intact tissue location for subsequent single-cell gene expression analysis.
A preprint by Sbierski-Kind et al. shows that IL-33-producing adventitial fibroblasts provide a stromal niche for ILC2s that limits IL-17-mediated liver fibrosis.
In this Tools of the Trade article, Xiaoyun Dai (of the Sidi Chen lab) developed a CRISPR-based platform termed CLASH to generate a large pool of precisely gene-modified CAR T cells, from which the most desirable variants could be selected.
Gillian Griffiths and colleagues show that T cell receptor downregulation at the immune synapse occurs through ectocytosis, which terminates receptor signalling and promotes dissociation from target cells.
A combination therapy of a tumour-targeted antibody–cytokine fusion protein and a chemotherapy drug shows promising results in preclinical testing and in a phase I study in patients with recurrent glioblastoma.