News & Comment

Prostaglandin E2 expression is increased and drives immunosuppression in patients with advanced liver disease.

NRROS is a negative regulator of reactive oxygen species (ROS) in phagocytes.

Local fibroblasts prevent mast cell activation in the skin by degrading retinoic acid.

In response to parasite infection, nitric oxide is produced not only by infected cells but also by recruited phagocytes.

IL-6 signalling in macrophages limits obesity-associated inflammation and the development of insulin resistance.

Retinoic acid promotes secondary lymphoid organ formation during embryogenesis to establish adult immunity.

Group 2 innate lymphoid cells are required to mount an effective type 2 immune response after the inhalation of allergens.

Inflammasome assembly involves prion-like polymerization of the pyrin domain of the adaptor ASC.

Differential chemokine induction by pathogens leads to the development of distinct tertiary lymphoid tissues.

Regulatory T cells promote the differentiation of T follicular helper cells.

The immunoglobulin superfamily member CD96 binds CD155 to negatively control cytokine production by natural killer cells.

Ultraviolet radiation-induced neutrophilic inflammation promotes melanoma metastasis.

Two new studies link human genetic variants with the innate immune response to infection.

A rapid TLR-induced increase in the rate of glycolysis is crucial for the activation of dendritic cells.

Human cytomegalovirus infection induces microRNA editing, which leads to decreased HLA-E expression by, and increased NK cell-mediated killing of, infected cells.

Tumour necrosis factor promotes chronic colitis by suppressing intestinal glucocorticoid synthesis.

Innate lymphoid cells enhance innate-like B cell responses in the spleen.

Albumin nanoparticles specifically target activated neutrophils.

Promiscuous lipid binding by the sorting adaptor TIRAP regulates TLR signalling from distinct subcellular locations.

IFNβ induces a novel population of FOXA1⁺regulatory T cells in the CNS.