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Mother mice retain a small population of latent regulatory T cells from each pregnancy that remembers their offspring and protects against future pregnancy complications.
In this Tools of the Trade article, Lisa Wagar (while in the Mark Davis lab) developed an in vitro immune organoid system from primary human lymphoid tissue that recapitulates productive adaptive immune responses.
A new study shows that even a short-term switch to a low-fibre diet suppresses immunity to bacterial infection and compromises effector T cell responses.
A study in Nature reports a lactate–HIF1α–NDUFA4L2 pathway in intestinal dendritic cells that regulates the inflammatory priming of encephalitogenic T cells.
In this Tools of the Trade article, Yury Goltsev and Garry Nolan describe a multiplexed tissue imaging technique called CODEX that enables rapid tissue staining with multiple DNA-barcoded antibodies.
Two studies in Nature describe the mechanisms that underlie allergen avoidance behaviour in mice, linking allergen sensing in the gut to a protective behavioural response to repeated ingestion of allergen.
A preprint by Rakebrandt, Yassini et al. investigates the role of CD4+ T helper cells in heterologous immunity, identifying a population of memory cells that have pro-inflammatory function in a T cell receptor-independent manner.