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Here, Alan Baxter provides an historical view of experimental autoimmune encephalomyelitis (EAE). Its value in providing insight into T–cell immunology is clear, but might the reductionist approach to EAE have hindered our appreciation of the polyantigenic responses that occur in multiple sclerosis and thereby its clinical relevance?
Diane Mathis and Christophe Benoist describe how our understanding of the function of autoimmune regulator (AIRE) has developed over the last decade, from its discovery to its role in central tolerance. Key questions that need to be addressed over the next decade are also highlighted.
