Research Highlights in 2010

Matrix component biglycan promotes CXCL13 expression to drive B cell-mediated renal inflammation.

Pre-existing antibodies specific for seasonal influenza virus promote severe disease during pandemics.

Neighbouring intestinal epithelial cells communicate to enhance antibacterial responses.

CD4⁺T cells mediate the effects of oncogene inactivation on tumour growth and survival.

Hypersensitive site 2 (HS2) is essential for GATA3-mediated epigenetic modifications at theIl4locus.

pDCs are an early, transient source of type I IFNs during skin injury and viral infection.

Regulatory T cell-mediated suppression of γδ T cells prevents spontaneous colitis.

T cell help is the limiting factor for high-affinity B cell selection in germinal centres.

The chemokine receptor CX₃CR1 promotes effector T cell survival in allergic lungs.

ER stress and atherogenic lipids trigger macrophage apoptosis in atherosclerotic lesions.

Microglial cells derive from primitive haematopoietic progenitors.

Fully differentiated monocyte-derived dendritic cells mobilize to lymph nodes in response to lipopolysaccharide.

CXCR6 signalling allows natural killer cell persistence in the liver and memory-like responses.

Neutrophil recruitment to sites of sterile inflammation involves a hierarchical series of cues.

Mechanism for the induction of endotoxin tolerance in neonatal intestinal epithelial cells.

A systemic acute-phase protein and crosstalk with NKT cells modulate neutrophil activity.

Activation of BATF by PD1 contributes to T cell exhaustion in HIV infection.

The anti-apoptotic protein MCL1 is crucial for germinal centre B cell responses.

Adipose tissue macrophages contribute to mopping up excess lipids during weight loss.