Comment in 2018

In this comment, Maziar Divangahi discusses the roles of disease tolerance and trained immunity in tuberculosis infection.

Scientists involved in the Human Cell Atlas Project describe its potential as a resource for future research and the challenges that lie ahead.

Quorum sensing is the regulation of gene expression programmes in response to changes in population density. It is probably best recognized as a mechanism through which bacterial communities can synchronize behaviours, such as biofilm formation and bioluminescence. This Comment article highlights the emerging evidence suggesting that quorum sensing also contributes to the regulation of immune cell responses.

Transcriptional signatures of disease can be used for diagnosis or to gain insight into disease mechanisms. This Comment article discusses the different sets of criteria that should be considered for the optimal design of investigations addressing these two purposes, using examples from the study of tuberculosis.