Browse Articles

Thymic B cells directly present self-antigen for T cell negative selection.

HBP is a pathogen-associated molecular pattern (PAMP) from Gram-negative bacteria that promotes immunity following cytosolic detection.

InvasiveSalmonelladisease is severe and represents a major public health problem worldwide. In this Review, the authors summarize our current understanding of host immunity to Salmonella and compare host genetic data from human and mouse studies.

Lymphatic vessels have been identified in the central nervous system.

An integrated DNA-binding domain in a plant immune receptor functions as a decoy to detect pathogen effectors that target host transcription factors.

Innate lymphoid cells (ILCs) are emerging as key regulators of the immune system, with different ILC subsets showing distinct immunological properties. This Review describes the transcriptional mechanisms that regulate the development and function of the different ILC subsets. The authors also discuss the evolving ILC nomenclature.

Although they are better known for their roles in antibody responses, B cells also contribute to immunity by secreting cytokines. Here, the authors discuss the various ways in which B cells can shape the immune response during infection and inflammatory disease by producing both pro-inflammatory and immunosuppressive cytokines.

Interferon-λ and interleukin-22 act synergistically to curtail rotavirus infection of intestinal epithelial cells.

Outer membrane vesicles access intestinal macrophages in a sulfatase-dependent manner where they induce inflammation in susceptible hosts.

This Review describes the type I interferonopathies — a set of Mendelian disorders associated with the upregulation of type I interferon activity. The authors explain how defects in key components of innate immune signalling pathways can lead to these diseases and discuss the immunological insights that have resulted from their study.

Type I interferons (IFNs) are best known for their role in antiviral immunity. As discussed in this Review, recent evidence indicates that these cytokines also have an integral role in natural and therapy-induced anticancer immunity. Harnessing the antineoplastic properties of type I IFNs may lead to the development of ever-more effective anticancer therapies.

Interleukin-7 supports metabolic activity in memory CD8⁺T cells, and should our paradigms of memory subsets be revised?

A newly identified protein, LEM, promotes CD8⁺T cell proliferation and memory formation.

In this Review, the authors describe how tumour necrosis factor (TNF) signals via its receptors. They explain how TNF is able to promote cell survival or cell death in different contexts and discuss the consequences of deregulated TNF receptor signalling for chronic human diseases. Finally, they discuss new strategies for targeting TNF in the clinic.

T helper 17 (T_H17) cells transdifferentiate into T regulatory type 1 (T_R1) cells and contribute to the resolution of inflammation in mice.