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Embryonic stem cells (ESCs) can be used as a source of cellular models for a wide range of adult differentiated cells, providing that reliable differentiation protocols are established. Here, Pouton and Haynes discuss challenges and opportunities regarding the use of ESC-derived models for drug discovery.
The intrinsic robustness of biological systems is a key factor preventing the success of potential drugs that target specific molecules. Using examples based on existing drugs, Kitano discusses how a greater consideration of the importance of robustness could influence the design of new drugs intended to control complex systems.
