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This Viewpoint advocates a radical rehaul of the system for describing breast pathology, to echo the classification systems used in other organs. Molecular alterations detected by comparative genomic hybridization highlight some of the deficiencies of the current system for differentiation of different types of breast tumors.
Epstein–Barr virus (EBV)-associated malignancies are a heterogenous group of tumors that are generally relatively radiosensitive and chemosensitive in their early stages, but less amenable to conventional modality therapy in late stage or relapse. New and emerging strategies to manipulate the immune response are discussed. These strategies are used either alone or as an adjuvant therapy in combination with chemotherapy with or without monoclonal antibodies.
Histone deacetylase inhibitors show significant activity against a broad spectrum of neoplasms, at doses that are well tolerated by cancer patients. These molecules control post-translational modification of histones, which is an important epigenetic regulation of gene expression. The discovery and development of suberoylanilide hydroxamic acid (SAHA), which is one of the most advanced compounds in this group, is the focus of this review.
Quality-of-life improvements and nutritional status are important in the management of cancer patients, but are often overlooked. Treatments for anorexia and cachexia are often attempted during the advanced stages of the disease. Cytokines and tumor-derived factors appear have a significant role in the pathogenesis of anorexia and cachexia. Laviano et al. discuss the pathogenesis and diagnosis of cachexia and anorexia, focusing on the dietary and drug interventions, which can prolong survival and positively influence quality of life for cancer patients.
