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Volume 19 Issue 11, November 2022

DEI in Cardiology, inspired by the Roadmap on p765.

Cover design: Vicky Summersby.

Editorial

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World View

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Comment

  • Mentorship is a crucial element to success and satisfaction among medical professionals. For a successful relationship, both mentors and mentees must examine their roles and goals. In this Comment article, a mentor–mentee pair discuss the necessary attributes for a productive partnership.

    • Martha Gulati
    • Priya Kohli
    Comment
  • Childbearing cardiologists face a number of challenges before, during and after pregnancy, including radiation concerns, infertility, pregnancy-related complications, and inadequate parental leave and return-to-work structures. Institutions can promote an equitable work environment by creating policies to mitigate these challenges.

    • Inbar Raber
    • Amy A. Sarma
    Comment
  • Globally, Black people have some of the highest rates of cardiovascular disease. Racial inequities in cardiovascular health must be tackled. Black In Cardio is a trainee-led initiative aimed at promoting Black people in the cardiovascular field and raising awareness about issues related to the cardiovascular health of Black communities.

    • Jason Amartey
    • Chichi Okagbue
    • Debora Kamin Mukaz
    Comment
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Research Highlights

  • In patients with heart failure (HF) with mildly reduced or preserved ejection fraction, the SGLT2 inhibitor dapagliflozin reduces the risk of worsening HF or cardiovascular death by 18%, reduces total HF events and cardiovascular deaths by 23% and improves HF symptoms, according to findings from the DELIVER trial.

    • Irene Fernández-Ruiz
    Research Highlight
  • In the SECURE trial, a polypill containing aspirin, ramipril and atorvastatin taken within 6 months after myocardial infarction reduces the risk of major adverse cardiovascular events compared with usual care.

    • Karina Huynh
    Research Highlight
  • Among patients in a coma after resuscitation for out-of-hospital cardiac arrest, a restrictive versus liberal oxygenation strategy, or a target mean arterial blood pressure of 77 mmHg versus a target of 63 mmHg, did not affect the risk of neurological disability or death.

    • Karina Huynh
    Research Highlight
  • Extravascular implantable cardioverter–defibrillators are safe and effective at detecting and terminating ventricular arrhythmias induced at the time of implantation.

    • Gregory B. Lim
    Research Highlight
  • An invitation to undergo comprehensive cardiovascular screening in men aged 65–74 years did not lower the incidence of death from any cause after 5 years in the DANCAVAS trial, but data suggest benefits in some outcomes and in reducing mortality in men aged < 70 years.

    • Irene Fernández-Ruiz
    Research Highlight
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Reviews

  • In this Review, Quiles and Gustafsson compare the physiological and pathophysiological roles of mitochondrial fission and discuss the therapeutic potential of preventing excessive mitochondrial fission in the heart and vasculature.

    • Justin M. Quiles
    • Åsa B. Gustafsson
    Review Article
  • In this Review, Khan and colleagues discuss the benefits and challenges of including pragmatism in the design, conduct and interpretation of randomized controlled trials (RCTs) for cardiovascular disease and highlight selected ongoing and completed cardiovascular RCTs that incorporate a pragmatic design.

    • Muhammad Shariq Usman
    • Harriette G. C. Van Spall
    • Muhammad Shahzeb Khan
    Review Article
  • Drugs can be repurposed for new therapeutic indications. In this Review, Mercola and colleagues summarize the latest techniques for systematic drug repurposing and re-engineering, which could increase the pace, efficiency and cost-effectiveness of drug discovery for the treatment of cardiovascular disease.

    • Mena Abdelsayed
    • Eric J. Kort
    • Mark Mercola
    Review Article
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Roadmap

  • Cardiovascular researchers face a range of challenges, including reduced grant funding, job insecurity and a lack of diversity in leadership roles. In this Roadmap article, Marques and colleagues propose strategies to overcome these challenges, focusing on three key areas: capacity building, research funding and fostering diversity and equity.

    • Niamh Chapman
    • Emma E. Thomas
    • Francine Z. Marques
    Roadmap
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