The underlying mechanisms for the continued sex-based disparities in acute coronary syndromes (ACS) remain unclear. In this Review, Pagidipati and Peterson discuss the current evidence for sex-related differences in the clinical presentation, pathophysiology, evaluation, management, and outcomes of ACS, and identify urgent research questions that need to be addressed in areas that range from clinical evaluation and management, to representation of women in clinical research.
- Neha J. Pagidipati
- Eric D. Peterson