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Misregulation of cyclin-dependent kinases (CDKs) can induce unscheduled proliferation and genomic and chromosomal instability. How has recent genetic evidence changed our understanding of the roles of CDKs in the cell cycle of normal and tumour cells?
Relapse remains almost inevitable for patients with advanced ovarian cancer. can the introduction of novel targeted therapies affect the management of this disease?
Thrombospondin 1, an endogenous angiogenesis inhibitor, affects nitric oxide signalling and therefore haemostasis and blood flow. What is the role of thrombospondin 1 in cancer and what can it teach us about therapeutic inhibition of angiogenesis?
Neurotransmitters released through the activation of nicotinic acetylcholine receptors (nAChRs) regulate the synthesis and release of growth, angiogenic and neurotrophic factors. Evidence suggests that smoking and possibly other factors increase the activity of certain nAChRs, and might therefore contribute to tumour development.
The question of how cells become malignant has occupied scientists for over a century. However, the converse question — are tumour cells capable of reverting from their malignant state — is also valid, as discussed in this article.
Gene amplification is an essential process in several organisms including the ciliateTetrahymena thermophila. What can amplification in this model system teach us about mechanisms of amplification in cancer cells?
