Volume 8 Issue 7, July 2008
From The Editors
In the News
Targeting the oncogene and kinome chaperone CDC37
CDC37 is oncogenic because it stabilizes the structures of mutated or overexpressed oncogenic kinases. Targeting this chaperone activity, on which many tumours depend, is therefore an attractive option for broad-based therapy.
Recurrent gene fusions in prostate cancer
Gene fusions have long been known to have an important role in leukaemias, but they have recently been identified in a majority of prostate cancers. Understanding their role in this disease could lead to better targeted therapies.
Living on a break: cellular senescence as a DNA-damage response
Cellular senescence is associated with ageing and cancerin vivoand has a proven tumour suppressive function. This Review discusses the evidence indicating that DNA damage and the engagement of the DNA-damage response pathways are common to both ageing and cancer.
MYB function in normal and cancer cells
The transcription factor MYB seems to have key roles as a regulator of epithelial stem and progenitor cells. Therefore,MYBis an oncogene that is involved in some human leukaemias, and could also be involved in epithelial cancers such as colorectal cancer and breast cancer.
Revisiting the biological roles of PAI2 (SERPINB2) in cancer
Of the two main urokinase plasminogen activator inhibitors, high tumour levels of the type 1 inhibitor promote tumour progression, whereas high levels of the type 2 inhibitor decrease tumour growth and metastasis. What might be the basis of this paradoxical action?
Exploring the role of cancer stem cells in radioresistance
Cancer stem cell content and the intrinsic radiosensitivity of cancer stem cells is thought to vary between tumours, thereby affecting their radiocurability. What do we know about cancer stem cells in radioresistance and how might this information be used?
Science and Society
Banking on cord blood stem cells
The controversy surrounding private, for–profit umbilical cord blood banks continues unabated. What is the scientific rationale for banking your child's cord blood for its potential future use against malignancy? Michael sullivan investigates.