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CDC37 is oncogenic because it stabilizes the structures of mutated or overexpressed oncogenic kinases. Targeting this chaperone activity, on which many tumours depend, is therefore an attractive option for broad-based therapy.
Gene fusions have long been known to have an important role in leukaemias, but they have recently been identified in a majority of prostate cancers. Understanding their role in this disease could lead to better targeted therapies.
Cellular senescence is associated with ageing and cancerin vivoand has a proven tumour suppressive function. This Review discusses the evidence indicating that DNA damage and the engagement of the DNA-damage response pathways are common to both ageing and cancer.
The transcription factor MYB seems to have key roles as a regulator of epithelial stem and progenitor cells. Therefore,MYBis an oncogene that is involved in some human leukaemias, and could also be involved in epithelial cancers such as colorectal cancer and breast cancer.
Of the two main urokinase plasminogen activator inhibitors, high tumour levels of the type 1 inhibitor promote tumour progression, whereas high levels of the type 2 inhibitor decrease tumour growth and metastasis. What might be the basis of this paradoxical action?
Cancer stem cell content and the intrinsic radiosensitivity of cancer stem cells is thought to vary between tumours, thereby affecting their radiocurability. What do we know about cancer stem cells in radioresistance and how might this information be used?
The controversy surrounding private, for–profit umbilical cord blood banks continues unabated. What is the scientific rationale for banking your child's cord blood for its potential future use against malignancy? Michael sullivan investigates.
