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Volume 23 Issue 1, January 2023

Riddle me this, inspired by the Perspective on p43.

Cover design: David Johnston; cover concept: Matthias Holländer.


  • Social media has revolutionized health-care communication across medicine, particularly in the field of oncology. In this Comment, Manochakian and Dizon highlight the role of social media in promoting patient-driven cancer research to benefit all.

    • Rami Manochakian
    • Don S. Dizon


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Research Highlights

  • In this study, Cao et al. identified previously undiscovered metabolites produced by human gut microbes that cause DNA damage, and analysed their implication for colorectal cancer development.

    • Daniela Senft
    Research Highlight
  • Schmitt et al. describe an adaptive mechanism employed by colorectal cancers to handle pro-apoptotic chemotherapeutic insults, which could represent a targetable vulnerability with combination therapy.

    • Anna Dart
    Research Highlight
  • Two recent studies have demonstrated how senescent cancer cells alter their cell surface proteome to induce anti-tumour immune responses, highlighting the potential therapeutic role of inducing senescence to improve anti-tumour immunity.

    • Gabrielle Brewer
    Research Highlight
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  • The activation of DNA damage tolerance (DDT) pathways as part of the replication stress response to DNA damage is key for maintaining genome integrity and, as a result, these pathways are closely linked to tumorigenesis. In this Review, Cybulla and Vindigni discuss the many connections between DDT, replication stress and cancer, detail opportunities for clinical biomarker development, and outline therapeutic strategies for targeting these pathways.

    • Emily Cybulla
    • Alessandro Vindigni
    Review Article
  • This Review covers recent advances in intravital imaging of mammalian models of cancer and describes how intravital imaging can help to understand the role of the tumour microenvironment in cancer progression and metastasis, and to develop novel treatments and therapies.

    • David Entenberg
    • Maja H. Oktay
    • John S. Condeelis
    Review Article
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  • In this Perspective, Wahida et al. consider six riddles in precision oncology that must be solved to achieve better clinical responses to molecular targeted therapies.

    • Adam Wahida
    • Lars Buschhorn
    • Razelle Kurzrock
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