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The number of people disclosing gender diverse identities is growing. We must act now to collect data on cancer incidence and outcomes, and promote inclusion in studies, in order to better understand cancer in this population and provide equitable cancer care.
Casanova-Acebes et al. show that tissue-resident macrophages provide a unique niche for tumour cells in the lung to promote invasiveness and regulatory T cell-mediated immune suppression.
Two studies published in Nature Cancer and Nature Communications describe the discovery of first-in-class, potent and specific inhibitors of Polϴ to target homologous recombination-deficient cancers.
Martirosian et al. show that a metabolic mechanism used by neurons and astrocytes during periods of nutrient deprivation and stress may have a role in leptomeningeal dissemination of medulloblastoma.
This Review discusses the unique and complex immunological and metabolic features of the liver, from the precancerous stage through to oncological transformation and metastasis. Strategies for targeting this niche are also considered.
The translational control of mRNAs during gene expression allows rapid, specific changes in the cell proteome. This Review describes the mechanisms underlying changes in mRNA translation in response to oncogenic signalling and microenvironmental stress, and how these changes can promote cancer onset, progression and resistance to anticancer therapies.
This Perspective highlights the importance of protein–protein interactions for the oncogenic functions of MYC and discusses how the MYC protein interactome might be exploited therapeutically.
Collective cancer cell invasion with leader–follower organization is a key mechanism of metastasis, but a consensus definition of leader cell characteristics is lacking. This Perspective outlines a conceptual framework for understanding how leader cells coordinate the invasion process using a multitude of cellular and molecular programmes.
