Volume 18 Issue 8, August 2018

Volume 18 Issue 8

'The computer will see you now', inspired by the Perspective on p500

Cover design: Lara Crow

Research Highlights

  • Research Highlight |

    Analyses of clinical trial patients with exceptional responses show that adoptive T cell therapy can be optimised to improve effectiveness in patients of chronic lymphocytic leukaemia and breast cancer.

    • Ulrike Harjes

    Collection:

  • Research Highlight |

    Tumour-associated neutrophils can inhibit the proliferation of pro-tumoural interleukin-17 (IL-17)+ γδ T cells via production of reactive oxygen species.

    • Anna Dart
  • Research Highlight |

    Increased shortening of RNA 3′ untranslated regions associated with tumorigenic transformation interferes with competing endogenous RNA (eRNA) networks, which results in trans-repression of tumour suppressors through microRNA-mediated silencing.

    • Paulina Strzyz
  • Research Highlight |

    Three studies published in Developmental Cell, Nature and Nature Medicine shed new light on mechanisms of cancer-associated cachexia in early and advanced disease.

    • Ulrike Harjes
  • Research Highlight |

    Breast tumours in mice promote metabolic changes in the liver and sleep disruption through increasing activity of hypocretin (also known as orexin) neurons (HO neurons).

    • Sarah Seton-Rogers
  • Research Highlight |

    Priego et al. show that a subpopulation of reactive astrocytes expressing signal transducer and activator of transcription 3 (STAT3) is crucial for the development of brain metastases and report positive initial clinical data that inhibiting STAT3 can reduce metastasis.

    • Sarah Seton-Rogers
  • Research Highlight |

    The gut microbiota can metabolize bile acids to affect immunosurveillance in the liver of mice and indirectly control the growth of primary liver tumours and liver metastases.

    • Anna Dart

Reviews

Perspectives

  • Perspective |

    In this Opinion article, Hosny et al. discuss the application of artificial intelligence to image-based tasks in the field of radiology and consider the advantages and challenges of its clinical implementation.

    • Ahmed Hosny
    • , Chintan Parmar
    • , John Quackenbush
    • , Lawrence H. Schwartz
    •  & Hugo J. W. L. Aerts
  • Perspective |

    This Opinion discusses the role of the primary cilium as a platform for pathways implicated in cancer and how changes in the ciliation of cells in the tumour microenvironment can affect cancer progression.

    • Hanqing Liu
    • , Anna A. Kiseleva
    •  & Erica A. Golemis

Correspondence

Amendments & Corrections