May 2017

Multifaceted effects of the microenvironment on tumour progression

Tumour progression is not only dictated by events within tumour cells, but also by whether the surrounding niche is permissive to growth at all stages of disease.

May 2012

Mitochondrial function and cancer

Mitochondria undertake multiple critical functions in a cell.

December 2011

Proteasome inhibition in cancer therapy

In recent years the ubiquitin–proteasome system has been identified as essential for maintaining a crucial balance between cell growth and death, the progression of human malignancies, and the development of drug resistance in cancer cells.

May 2011

The emerging biology of cancer stem cells

Cancer stem cells (CSCs) are cells with properties that are similar to those described for tissue stem cells: self renewal and asymmetric division resulting in the generation of daughter cells destined to differentiate, enabling the regeneration of a tissue.

June 2010

The DNA damage response in tumorigenesis and cancer treatment

The DNA damage response pathways can activate cell cycle checkpoints (which can involve p53) to arrest the cell either transiently or permanently (senescence) or they can activate specific DNA repair pathways in response to certain types of DNA damage.

December 2009

The rise of p53

In 1979 the discovery of p53 was reported. The gene encoding p53 (TP53) was initially believed to be an oncogene but 10 years later it was correctly characterized as a tumour suppressor, which led to a steep rise in p53 research.

September 2007

The evolution of genetically engineered mouse models of cancer

Genetically engineered mouse models of cancer have taught us much about how cancer develops.

December 2006

Molecular mechanisms of stem-cell identity and fate

Stem cells have been identified and characterized in several mammalian tissues.

May 2005

Targeting cancer pathways

Tumour formation and progression occur through a range of defects that develop both within and outside the cancer cell.

May 2002

A subway map of cancer pathways

ancer arises from the stepwise accumulation of genetic changes that confer upon an incipient neoplastic cell the properties of unlimited, self-sufficient growth and resistance to normal homeostatic regulatory mechanisms.