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In this Tools of the Trade article, Xiwen Tang describes the development of in vivo reporters detecting mutant p53 at the protein level, which enables the visualization of precancerous cells during cancer initiation.
In this Tools of the Trade article, Hongcheng Mai describes the development of wildDISCO, an approach for whole-body immunolabelling, optical clearing and imaging in mice.
In this Tool of the Trade article, Nicolas Mathey-Andrews describes the generation and use of a prime editor mouse that enables in vivo modelling of the multitude of cancer alleles found in human tumours.
In this Tools of the Trade article, Dezhong Ji describes the development and use of a chimeric antigenic peptide influenza virus (CAP-Flu) system as a cancer vaccine strategy to promote tumour-infiltrating T cell activation in lung metastasis.
In this Tools of the Trade article, Chiara Cattaneo describes the development of HANSolo, a high-throughput genetic platform for the personalized identification of CD4+ and CD8+ T cell-recognized (neo)antigens, that can be used to generate patient-specific TCR gene therapies or cancer vaccines.
In this Tools of the Trade article, Emmanuel Olivier describes an approach to reprogramming AML cancer cells into induced pluripotent stem cells, which provide faithful genetic models of the most common genetic subgroups of AML.
In this Tools of the Trade article, Yuan Ma describes the development and use of ARPLA, a spatial imaging tool that can be used to visualize glycoRNAs in single cells, including cancer cells in situ.
In this Tools of the Trade article, Ciaran Seath describes the development and use of a proximity labelling method to study how cancer driving mutations and small molecule ligands remodel the chromatin microenvironment.
In this Tools of the Trade article, Isabel Esain-Garcia describes the development and use of a 6-letter whole-genome sequencing technology, which enables the simultaneous acquisition of genetic and epigenetic information from human genomic and cell-free DNA, which has implications for improving our biological understanding of cancer as well as cancer diagnosis and early intervention.
In this Tool of the Trade article, Eva Freckmann describes the development of Traject3d, a workflow that enables the detection of heterogeneous phenotypes in 3D culture by analysing label-free multi-day time-lapse imaging.
In this Tools of the Trade article, Zhenqin Wu describes the development and use of SPACE-GM, a graph deep learning tool that enables the detection of spatial cellular structures predictive of outcomes of patients with cancer.
In this Tool of the Trade article, Tatiana Flisikowska describes the development and use of humanized minipigs that allow the preclinical safety testing of human therapeutic antibodies.
In this Tool of the Trade article, Mateusz Legut describes the development and use of OverCITE-seq, a new single-cell multiomics approach enabling the high-throughput quantification of the transcriptome and surface antigens in cells expressing a library of open reading frames.
In this Tools of the Trade article, Alexandros P. Drainas describes the development and use of EpicMIBI, a multiplexed imaging technology that enables the study of spatial clonality in cancer.
In this article, Efrat Shema describes EPINUC, a liquid biopsy method based on epigenetic profiling of nucleosomes from cell-free DNA in the plasma. EPINUC, combined with protein biomarker measurements, enables the accurate differentiation of samples from healthy volunteers and patients.
In this Tools of the Trade article, Francisco Barriga describes the development and use of MACHETE, a flexible deletion engineering strategy, which enables the functional characterization of the large genomic deletions that occur in cancer.
In this Tools of the Trade article, Susan Bullman describes the development and use of INVADEseq, a single-cell RNA sequencing approach that facilitates the simultaneous capture of both eukaryotic and bacterial transcripts in host cells to functionally understand the intratumoural microbiota.
In this Tools of the Trade article, Lee describes Select-seq, a novel method for generating epitranscriptomic data from microniches within the tumour. The author reveals how the method can be used to identify novel biomarkers from rare cell subpopulations such as cancer stem cells in tumours.
