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In this Tools of the Trade article, Yuan Ma describes the development and use of ARPLA, a spatial imaging tool that can be used to visualize glycoRNAs in single cells, including cancer cells in situ.
Girish et al. designed a method to genetically remove extra chromosomes from human aneuploid cancer cells to show that they are important for malignant growth and not just a bystander.
Inducing ferroptosis in cancer cells has become a realistic method for promoting cancer cell death. In this study, Nakarmua et al. identify a novel ferroptosis suppressor 1 (FSP1) inhibitor that promotes FSP1 relocalization through phase separation, priming ferroptosis and ultimately impairing tumour growth.
Two independent studies published in Nature have collectively addressed the long-standing question of sex bias in cancer and implicated non-hormonal genes of the Y chromosome in aggressive features of colorectal and bladder cancers in men.
In this study, Malladi and colleagues reveal the mechanism by which mitochondrial fragmentation enables latent brain metastatic breast cancer cells to increase fatty acid oxidation to maintain cellular energetics and redox homeostasis.
In this Tools of the Trade article, Ciaran Seath describes the development and use of a proximity labelling method to study how cancer driving mutations and small molecule ligands remodel the chromatin microenvironment.
Wang et al. demonstrate how tumour-derived extracellular vesicles and particles dysregulate liver function to promote fatty liver disease and diminish chemotherapeutic efficacy.
In this Tools of the Trade article, Isabel Esain-Garcia describes the development and use of a 6-letter whole-genome sequencing technology, which enables the simultaneous acquisition of genetic and epigenetic information from human genomic and cell-free DNA, which has implications for improving our biological understanding of cancer as well as cancer diagnosis and early intervention.
In this Tool of the Trade article, Eva Freckmann describes the development of Traject3d, a workflow that enables the detection of heterogeneous phenotypes in 3D culture by analysing label-free multi-day time-lapse imaging.
In this study, Insco et al. find patient-specific CDK13 mutations to impede RNA surveillance, leading to the accumulation and translation of prematurely terminated RNAs that drive malignancy in melanoma models.
Sloan and colleagues demonstrate that anthracycline chemotherapy drives metastatic progression by stimulating a cancer cell-mediated increase in nerve fibre activity in the tumour microenvironment, which can be reversed by the use of β-blockers.
In a recent study on castration-resistant prostate cancer, Cui et al. uncover a role for cancer-associated fibroblasts (CAFs) in inducing androgen synthesis in prostate cancer cells.
In a recent Nature study, Hill et al. provide mechanistic evidence that air pollution promotes lung tumorigenesis in cells with pre-existing oncogenic mutations.
In this Tools of the Trade article, Zhenqin Wu describes the development and use of SPACE-GM, a graph deep learning tool that enables the detection of spatial cellular structures predictive of outcomes of patients with cancer.
Blanpain and colleagues provide evidence that the small RHO GTPase, RHOJ, mediates resistance to chemotherapy in tumour cells that have undergone epithelial-to-mesenchymal transition by enabling these cells to tolerate replicative stress and promote DNA damage repair.
