Research Highlights in 2011

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  • A new study identifies four genes as drivers of PCA progression and as a signature with prognostic value for predicting the risk of developing metastatic PCA.

    • Teresa Villanueva
    Research Highlight

  • Exposure of mouse skin to UVB early in life generates macrophage infiltration and an interferon-γ response that promotes melanocytic survival, evasion of the immune response and oncogenesis.

    • Nicola McCarthy
    Research Highlight

  • The cancer stem cell marker CD44 is a target of the tumour suppressive microRNA, miR-34a.

    • Nicola McCarthy
    Research Highlight

  • A new algorithm that combines gene expression and copy number alterations to identify driver genes and their possible function is reported. This was applied to melanoma samples, and vesicular trafficking was found to be an important process in this type of cancer.

    • Gemma K. Alderton
    Research Highlight

  • A new phenomenon in which tens to hundreds of genomic rearrangements are acquired in one step has been identified.

    • Teresa Villanueva
    Research Highlight

  • The RAC-GEF PREX1 integrates signals from tyrosine kinase receptors and GPCRs to activate RAC1.

    • Nicola McCarthy
    Research Highlight

  • Medulloblastomas with a mutation in the Wnt pathway arise from cells that are distinct from those affected by mutations in the SHH pathway.

    • Nicola McCarthy
    Research Highlight

  • The Hippo pathway couples cell polarity complexes to extrinsic signalling pathways.

    • Alison Schuldt
    Research Highlight

  • A new study identifies a regulatory mechanism controlling carbon source uptake.

    • Darren J. Burgess
    Research Highlight