Research Highlights in 2010

A selective TORC1 and TORC2 active site inhibitor has high efficacy and tolerability in models of acute leukaemia.

A paracrine signalling pathway between tumour cells and tumour-associated macrophages has been characterized.

The proportion of cancer stem cells might underpin differencies between poorly and well-differentiated breast cancers.

Cooperative signalling between two tumour clones expressing different oncogenic mutations is reported.

Monoglyceride lipase levels are increased in aggressive tumours, provide the principal source of free fatty acids and increase the production of biologically active lipids.

New insight into how Bub1 and BUBR1 prevent chromosomal instability.

Four recent papers detail changes in the cancer genome.

Mutant p53 promotes cell migration and invasion through integrin recycling.

Functional computational analysis of microarray data.

PIAS1 and PIAS4 promote BRCA1 sumoylation and DNA repair.

Genomic and transcriptomic analyses of Tasmanian devil facial tumour disease.

CDK2 influences MYC- and Ras-induced senescence.

A new technique for diagnosing cancer from limited amounts of tissue.

Identification of a small transcription factor network that is responsible for the mesenchymal behaviour of glioma cells.

TheIgh 3′ regulatory region (Igh3′ RR) can function over long distances to activate the transcription of translocated Myc.

How does ZEB1 regulate self-renewal and migration?

Hyperactive AID can result in widespread genomic damage and lymphoma.

Signals from EphB receptors that trigger cell proliferation and migration are mediated by two distinct downstream pathways.

TAp63 induces senescence and suppresses tumour growth in vivo.

Missense mutations of IDH1 confer oncogenic gain-of-function properties.