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Volume 17 Issue 4, April 2021

Phase separation in the nucleus

Biomolecules in the cell nucleus form condensates at a rate slower than that predicted by the theory of droplet growth. Experiments on living cells attribute this anomalous coarsening behaviour to subdiffusive dynamics in the crowded nucleus. The image is a composite fluorescence micrograph of live human osteosarcoma cells, showing the co-localization of nuclear droplets and chromatin, using a spinning disk confocal microscope.

Brangwynne, Article

IMAGE: Daniel S. W. Lee, Princeton University. COVER DESIGN: Allen Beattie.

Editorial

  • The US Department of Justice’s ‘China Initiative’ is unfairly targeting Chinese American academics for their alleged ties with the Chinese government. A more proportionate approach is urgently needed.

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Thesis

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Comment

  • Scientific progress has always been driven by the ability to build an instrument to answer a specific question. But spreading the news of how to replicate that tool is an evolving art, ripe for an open-source revolution.

    • Georg E. Fantner
    • Andrew C. Oates
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News & Views

  • With increasing neutron number, the size of a nucleus grows, subject to subtle effects that act as fingerprints of its internal structure. A fresh look at potassium calls for theory to decipher the details.

    • Gianluca Colò
    News & Views
  • A clever application of nuclear magnetic resonance techniques offers a glimpse at a quantum system driven at high frequency, resulting in Floquet prethermalization — a quasi-steady state that persists for a very long time.

    • Lea F. Santos
    News & Views
  • Two experiments using entangled photons have successfully generated more randomness than consumed — at a level of security that is all but certain. They did so by exploiting non-locality, one of the most counterintuitive aspects of quantum mechanics.

    • Paul Skrzypczyk
    News & Views
  • Among the many reasons a signal may deviate from perfect periodicity, quantum-limited jitter is arguably the most fundamental. A clever experiment has now stripped away technical noise to unveil quantum-limited jitter of ultrafast soliton frequency combs.

    • Miro Erkintalo
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  • The magnetic properties of intercalated metal dichalcogenides are dramatically affected by small crystal imperfections, potentially providing design principles and materials for spintronic devices.

    • Minhyea Lee
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  • Biophysicists have long sought to probe the physical properties of the cell nucleus, but the sheer size of this tiny organelle puts limits on its exploration. The coarsening of biomolecular droplets looks set to give us the inside scoop.

    • Alexandra Zidovska
    News & Views
  • The unavoidable effects of noise make quantum error correction necessary to realize the full potential of quantum computers. Devices that correct errors autonomously can avoid the computational and hardware overheads of traditional approaches.

    • Joshua Combes
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Measure for Measure

  • What does it mean for an individual to be ‘important’ or for a connection to be ‘outstanding’? The answer depends on context, as Sarah Shugars and Samuel V. Scarpino explain.

    • Sarah Shugars
    • Samuel V. Scarpino
    Measure for Measure
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